|Year : 2016 | Volume
| Issue : 1 | Page : 25
Validity and reliability of the persian version of the PEReption de la scle'rose en plaques et de ses pousse'es questionnaire evaluating multiple sclerosis-related quality of life
Mahsa Ghajarzadeh1, Sepehr Azizi2, Abdorreza Naser Moghadasi3, Mohammad Ali Sahraian3, Amirreza Azimi3, Mehdi Mohammadifar4, Amirhossein Mohammadian Bajgiran5
1 Brain and Spinal cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Tehran University of Medical Sciences, Tehran, Iran
3 MS research center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
4 Zanjan University of Medical Sciences, Zanjan, Iran
5 Department of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
|Date of Submission||12-Jul-2014|
|Date of Acceptance||04-Sep-2015|
|Date of Web Publication||22-Jan-2016|
Brain and Spinal cord Injury Research Center, Tehran University of Medical Sciences, Tehran
Source of Support: None, Conflict of Interest: None
Background: Multiple sclerosis (MS) affects all aspects of patients. Recently, the "PERception de la Scle'rose En Plaques et de ses Pousse'es" (PERSEPP) scale was designed to assess MS-related relapse on quality of life (QoL). The aim of this study was to evaluate validity and reliability of Persian version of PERSEPP scale in Iranian patients with MS.
Methods: Two-hundred eleven patients with relapsing-remitting form of the disease asked to fill the PERSEPP scale, MSQOL-54, and SF-36 questionnaires. Fifty cases filed the questionnaire 2 weeks later to assess reliability. The intraclass correlation coefficient (ICC) and Cronbach's alpha analysis were used.
Results: Mean age and mean duration of disease were 32.2 ± 8.4 years and 6.5 ± 2.5 years, respectively. One hundred sixty-seven (79.1%) were female and 44 (20.9%) were male. Forty-one (19.4%) were in relapse phase of the disease. ICC score of all items was above 0.8. Cronbach's alpha of all items was above 0.8. The results show that the mean scores of four items (relationship difficulties, time perspective, and symptoms) were significantly different between cases in relapse and none relapse. Coping and relationship difficulties scores were significantly different between different expanded disability status scale groups. Pearson correlation score for QoL 54 and PERSEP calculated as r = 0.44, P < 0.001 and r = 0.66, P < 0.001 between SF36 and PERSEP.
Conclusions: Persian version of PERCEPP questionnaire provides valid and reliable instrument to assess MS-related QoL.
Keywords: Multiple sclerosis, Persian, quality of life
|How to cite this article:|
Ghajarzadeh M, Azizi S, Moghadasi AN, Sahraian MA, Azimi A, Mohammadifar M, Bajgiran AM. Validity and reliability of the persian version of the PEReption de la scle'rose en plaques et de ses pousse'es questionnaire evaluating multiple sclerosis-related quality of life. Int J Prev Med 2016;7:25
|How to cite this URL:|
Ghajarzadeh M, Azizi S, Moghadasi AN, Sahraian MA, Azimi A, Mohammadifar M, Bajgiran AM. Validity and reliability of the persian version of the PEReption de la scle'rose en plaques et de ses pousse'es questionnaire evaluating multiple sclerosis-related quality of life. Int J Prev Med [serial online] 2016 [cited 2020 Sep 29];7:25. Available from: http://www.ijpvmjournal.net/text.asp?2016/7/1/25/174773
| Introduction|| |
Multiple sclerosis (MS) is a chronic auto immune disease that affects all aspects of patient's lives. ,, Physical, emotional, cognitive, intellectual, sexual, and social feature of their lives are impaired. ,, Health-related quality of life (QoL) is defined as individual's perception of function and health further than the contemporary condition. Previous studies demonstrated that QoL is impaired in cases with MS. , Nearly, 85% of the patients present with relapsing-remitting (RR) form of the disease.  In relapse phase, new clinical signs, the reappearance of old symptoms, or the worsening of preexisting symptoms occurs.  Relapses are not predictable and have negative impact on QoL.  In a previous study, there was significant difference between QoL scores in relapse and nonrelapse phases.  Different scales have been developed for QoL assessment in MS cases, but none of these scales focus on relapse phase.
Recently, the "PERception de la Scle'rose En Plaques et de ses Pousse'es" (PERSEPP) scale was designed specifically for RR MS patients to assess MS-related relapse on QoL.  Different aspects such as social support, difficulties with social relationships, fatigue, state of mind and sleep, time perspective, coping, symptoms, and perception of treatment are included in the PERSEPP scale. The aim of this study was to evaluate validity and reliability of Persian version of PERSEPP scale in Iranian patients with MS.
| Methods|| |
In this cross-sectional study, 250 patients with RR type of MS who referred to MS Clinic of Sina Hospital (affiliated to Tehran University of Medical Sciences) were enrolled. The inclusion criteria were definite MS due to McDonald criteria  and RR type of the disease. Two groups of patients enrolled: Patients in relapse and those who were not in relapse at the time of study.
All cases were asked to fill the informed consent forms. The study had been approved by the local Ethics Committee.
Demographic data (sex and age), duration of the disease, marital status, and types of medications were recorded. The Kurtzke expanded disability status scale (EDSS) was recorded after examination by an expert neurologist.
Using the forward-backward translation method, PERSEPP questionnaire was translated into the Persian by two medical physicians in the field of research, and then Persian version was translated again into English. Two independent neurologists compared the translated English version with the original English version (content validity).
The PERSEPP questionnaire includes 66 questions; each question contains six response types where "0" was "strongly disagree" and "5" was "strongly agree" according to a Likert scale. It includes scales such as social support, relationship difficulties, satisfaction with care, fatigue, state of mind and sleep disorders, time perspective, and coping (module) as symptoms (module) and treatment (module).
The scores should be transformed to a range of 0-100, where 100 was the best QoL possible. The higher the score is the better the QoL of the patients.
Participants were asked to answer the valid and reliable Persian version of the MSQOL-54 and SF-36 questionnaires (convergent validity).
MSQOL-54 is a structured, self-report questionnaire containing 14 subscales (physical function, role limitations-physical, role limitations-emotional, pain, emotional well-being, energy, health perceptions, social function, cognitive function, health distress, overall QoL, sexual function, satisfaction with sexual function, and change in health). 
Sum of subtotals such as physical function, health perceptions, energy/fatigue, role limitation-physical, pain, sexual function, social function, and health distress makes the physical health composite and sum of subtotals such as health distress, overall QoL, emotional well-being, role limitation-emotional, and cognitive function makes the mental health composite. The higher the score is the better the QoL.
The SF-36 questionnaire consists of 36 questions in eight aspects and is an instrument for the evaluation of the QoL. All questions are scored on a scale of 0-100, with 100 representing the highest level of functioning possible. Higher scores indicate less impairment in the QoL. The questionnaire consists of eight subscales such as physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/fatigue, emotional well-being, social functioning, pain, and general health. 
In order to perform test-retest assessment, 50 patients filled the questionnaire 2 weeks after the first completion.
All data were analyzed using SPSS software version 20 (SPSS Inc., Chicago, IL, USA). Data were presented as mean ± standard deviation for continuous or frequencies for categorical variables. The intraclass correlation coefficient (ICC) was measured for repeatability evaluation, and ICC coefficient over 0.70 was considered acceptable. Cronbach's alpha was calculated in each three-factor of the questionnaire to assess the internal consistency reliability. Cronbach's alpha coefficient ≥0.70 was considered excellent reliability. Correlation coefficient along with the partial correlation coefficient was calculated for assessing the relationship between PERSEPP questionnaire scores and other variables.
| Results|| |
Finally, 211 completed questionnaires collected (response rate: 84%).
Mean age and mean duration of disease were 32.2 ± 8.4 years and 6.5 ± 2.5 years, respectively. One hundred sixty-seven (79.1%) were female and 44 (20.9%) were male. Eighty-five (40.3%) were single, 121 (57.3%) were married, and 5 (2.4%) were divorced. One hundred twenty-three (58.3%) were unemployed and 88 (41.7%) were employed. Forty-one (19.4%) were in relapse phase of the disease. ICC score of all items was above 0.8 [Table 1].
Cronbach's alpha of all items was above 0.8 [Table 2].
Pearson correlation score for QoL54 and PERSEP calculated as r = 0.44, P < 0.001 and r = 0.66, P < 0.001 between SF36 and PERSEP.
Except four items, mean scores of different items were significantly different between cases with and without relapse [Table 3].
|Table 3: Mean scores of different items in cases with and without relapse |
Click here to view
Coping and relationship difficulties scores were significantly different between different EDSS groups [Table 4].
| Discussion|| |
The aim of this study was to determine validity and reliability of the Persian version of PERCEPP questionnaire in a sample of Iranian MS patients.
The high ICC values are indicative of the high reliability of the Persian version of PERCEPP questionnaire. We also found that Cronbach's alpha of each factor is high and indicative of acceptable internal consistency. In a previous study conducted by Baroin et al., Cronbach's α of all items except coping were more than or equal to 0.7. Their results also showed that ICC score of all items was above 0.7, which are consistent with our results. 
The results show that the mean scores of four items (relationship difficulties, time perspective, and symptoms) were significantly different between cases in relapse and none relapse ones that could show discriminant validity of these items. In Baroin et al. study, time perspective, treatment, and symptoms were significantly different between relapse and none relapse ones.  The different between symptom scale could show clinical differences between relapse and none relapse cases. On the other hand, disturbances and concerns met in the relapse PERIOD could explain the difference of time perspective scale.
Total score of PERCEPP questionnaire was significantly correlated with SF36 and QoL54 questionnaires that could show convergent validity that is consistent with Baroin et al., study.  In their study, symptoms and treatment subscales were significantly different between cases with different EDSS scores while in this study, mean relationship difficulties and coping were significantly different. This could be indicative of impact of advanced disease on managing the personal and inter personal relations.
Nowadays, considering QoL in patients with MS is an important issue in the field of neurology.  Different questionnaires such as SF36 and MS-QoL54 have been applied for this purpose, but they do not focus on relapse phase of the disease. The relapse phase has negative effect on patient's QoL and it has especial effect on psychological and social dimensions.  So, the PERSEPP scale that is designed for RR MS patients is valuable to assess QoL in MS patients and impact of relapse phase on their QoL. This scale helps physicians to consider aspects of QoL of patients in relapse and nonrelapse phases.
| Conclusions|| |
Persian version of PERCEPP questionnaire provides a valid and reliable instrument to assess MS-related QoL.
| References|| |
Ghajarzadeh M, Sahraian MA, Fateh R, Daneshmand A. Fatigue, depression and sleep disturbances in Iranian patients with multiple sclerosis. Acta Med Iran 2012;50:244-9.
Ghajarzadeh M, Jalilian R, Eskandari G, Sahraian MA, Azimi A, Mohammadifar M. Fatigue in multiple sclerosis: Relationship with disease duration, physical disability, disease pattern, age and sex. Acta Neurol Belg 2013;113:411-4.
Ghajarzadeh M, Jalilian R, Eskandari G, Ali Sahraian M, Reza Azimi A. Validity and reliability of Persian version of Modified Fatigue Impact Scale (MFIS) questionnaire in Iranian patients with multiple sclerosis. Disabil Rehabil 2013;35:1509-12.
Ghajarzadeh M, Owji M, Sauraian MA, Naser Moghadasi A, Azimi A. Emotional Intelligence (EI) of Patients with Multiple Sclerosis (MS). Iran J Public Health 2014;43:1550-6.
Ghajarzadeh M, Jalilian R, Mohammadifar M, Sahraian MA, Azimi A. Sexual function in women with multiple sclerosis. Acta Med Iran 2014;52:315-8.
Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: Dimensions and contributory factors. J Res Med Sci 2014;19:228-33.
Hopman WM, Coo H, Edgar CM, McBride EV, Day AG, Brunet DG. Factors associated with health-related quality of life in multiple sclerosis. Can J Neurol Sci 2007;34:160-6.
Grima DT, Torrance GW, Francis G, Rice G, Rosner AJ, Lafortune L. Cost and health related quality of life consequences of multiple sclerosis. Mult Scler 2000;6:91-8.
Weinshenker BG. Epidemiology of multiple sclerosis. Neurol Clin 1996;14:291-308.
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al.
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001;50:121-7.
Halper J. The psychosocial effect of multiple sclerosis: The impact of relapses. J Neurol Sci 2007;256 Suppl 1:S34-8.
Ozakbas S, Cagiran I, Ormeci B, Idiman E. Correlations between multiple sclerosis functional composite, expanded disability status scale and health-related quality of life during and after treatment of relapses in patients with multiple sclerosis. J Neurol Sci 2004;218:3-7.
Baroin A, Mokadym H, Chopard G, Lavier A, Berger E, Rumbach L, et al.
Establishing an evaluation scale for the perception of quality of life related to relapsing-remitting forms of multiple sclerosis and feasibility study. Int J Neurosci 2012;122:9-16.
Polman CH, Reingold SC, Banwell B, Clanet M, Cohen JA, Filippi M, et al.
Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292-302.
Ghaem H, Borhani Haghighi A, Jafari P, Nikseresht AR. Validity and reliability of the Persian version of the multiple sclerosis quality of life questionnaire. Neurol India 2007;55:369-75.
Montazeri A, Goshtasebi A, Vahdaninia M, Gandek B. The Short Form Health Survey (SF-36): Translation and validation study of the Iranian version. Qual Life Res 2005;14:875-82.
Baroin A, Chopard G, Siliman G, Michoudet C, Vivot A, Vidal C, et al.
Validation of a new quality of life scale related to multiple sclerosis and relapses. Qual Life Res 2013;22:1943-54.
Solari A. Role of health-related quality of life measures in the routine care of people with multiple sclerosis. Health Qual Life Outcomes 2005;3:16.
[Table 1], [Table 2], [Table 3], [Table 4]
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