• Users Online: 85
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Browse Articles Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 26

Can antidepressant drug impact on blood pressure level in patients with psychiatric disorder and hypertension? A randomized trial


1 Department of Radiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Cardiology, Cardiac Electrophysiology Center, Afshar Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
3 Department of Cardiology, Nohom Dey Hospital, Torbat e Heydarie University of Medical Sciences, Torbat e Heydarie, Iran
4 Department of Cardiology, Cardiac Electrophysiology Center, Kashan University of Medical Sciences, Kashan, Iran
5 Isfahan Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
6 Cardiac Rehabilitation Research Center, Afshar Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran
7 Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran
8 Department of Anesthesiology, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Seyedmostafa Seyedhosseini
Afshar Hospital, Yazd University of Medical Sciences, Yazd
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2008-7802.174891

Rights and Permissions

Background: High blood pressure (BP) has been known as a major risk factor for many chronic diseases. It should be noted, a psychiatric disorder which is common in the people living modern lifestyle may be one of the leading causes of hypertension, and many people are prescribed antidepressant each year. Hence, the purpose of this study was to evaluate the effect of selective serotonin reuptake inhibitors (SSRIs) and alprazolam which defined as antidepressant on the BP levels, and to compare the BP levels between the group of users and nonusers. Methods: This randomized clinical trial study was conducted at the Nohom Dey Hospital in the Torbat-e Heydarieh, Iran between December 2011 and March 2012. Participants comprised 101 psychiatric patients with hypertension that randomly separated into users and nonusers of antidepressant. The period of intervention lasted for 3 months. The mean of BP calculated by this formula (systolic BP [SBP] +2 diastolic BP [DBP])/3 which was the main outcome of the study. Results: Users of antidepressant drugs did not have any significant changes in BP levels, except in patients who received SSRIs alone, significant improvement was observed in DBP (P = 0.04) and mean of BP (P = 0.03). While, in nonusers of antidepressant, significant development was observed in DBP, and mean of BP. Comparing the users and nonusers did not show any significant differences in SBP, DBP, and Mean of BP; even, when outcomes were adjusted for risk factors and antihypertensive drugs. Conclusions: Three months treatment with SSRIs and alprazolam did not have any effect on lowering BP level in patients with the psychiatric disorder.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2336    
    Printed39    
    Emailed0    
    PDF Downloaded202    
    Comments [Add]    
    Cited by others 1    

Recommend this journal