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 Table of Contents  
LETTER TO EDITOR
Year : 2016  |  Volume : 7  |  Issue : 1  |  Page : 9

Comment on: Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in male rats


Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt

Date of Submission25-Apr-2015
Date of Acceptance30-Jul-2015
Date of Web Publication13-Jan-2016

Correspondence Address:
Amr Ahmed El-Arabey
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2008-7802.173905

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How to cite this article:
El-Arabey AA. Comment on: Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in male rats. Int J Prev Med 2016;7:9

How to cite this URL:
El-Arabey AA. Comment on: Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in male rats. Int J Prev Med [serial online] 2016 [cited 2020 Apr 3];7:9. Available from: http://www.ijpvmjournal.net/text.asp?2016/7/1/9/173905

Dear Editor,

I read with interest a recently published article in the "Journal of Nephropathology" by Motamedi et al., entitled "Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in male rats." [1] The authors have concluded that low dose of pomegranate flower extract (PFE) (25 mg/kg) showed protective effects against cisplatin (CP)-induced nephrotoxicity through its antioxidant effects. On the other hand, they did not observed the protective role of a higher dose of PFE (50 mg/kg) versus CP-induced nephrotoxicity in the same animal model. They attributed these effects to the antioxidant dose, because high doses of some antioxidants do not have a protective effect, and can exacerbate tissue damage. [2],[3] Here, I would like to explain the potential mechanism may be related to this difference. The CP-induced nephrotoxicity is a gender dependent; the greater intensity of damage in male than female. [4] Gender differences of CP-induced nephrotoxicity may be related to CP uptake by OCT2; which has been demonstrated to be higher expressed in male than in female rats. [5] Thus, CP uptake was increased by OCT2 overexpression in male rats and associated with increased cellular sensitivity to CP toxicity. [6] A study demonstrated that OCT2 level was significantly reduced in mice after castration. [7] Moreover, a recent study concluded that CP therapy should be avoided when the serum testosterone (TS) level is high because TS in high concentrations (the selected doses: 50 mg/kg and 100 mg/kg) promote CP-induced nephrotoxicity in surgical castrated rats. [8] Furthermore, a recent study showed that the low dose of TS (10 mg/kg) protects kidneys against CP-induced nephrotoxicity in surgical castrated rats. [8] Subsequently, It seems the protective effect of TS on CP-induced nephrotoxicity depend on its dose. In addition, several studies concluded that the consumption of PFE increases significantly TS level in male rats. [9] Finally, I suggest the low dose of PFE (25 mg/kg) increase TS level closed to physiological normal level; however, the high dose of PFE (50 mg/kg) increase TS level in manner leads to increase gene expression of OCT2. Therefore, low dose of PFE showed protective effects; in contrast, the high dose of PFE exacerbate tissue damage resulting from increased CP uptake by OCT2 overexpression in male rats and associated with increased cellular sensitivity to CP toxicity.

 
  References Top

1.
Motamedi F, Nematbakhsh M, Monajemi R, Pezeshki Z, Talebi A, Zolfaghari B, et al. Effect of pomegranate flower extract on cisplatin-induced nephrotoxicity in rats. J Nephropathol 2014;3:133-8.  Back to cited text no. 1
    
2.
Azarkish F, Nematbakhsh M, Fazilati M, Talebi A, Pilehvarian AA, Pezeshki Z, et al. N-acetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. Int J Prev Med 2013;4:1139-46.  Back to cited text no. 2
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3.
Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7.  Back to cited text no. 3
    
4.
Nematbakhsh M, Ebrahimian S, Tooyserkani M, Eshraghi-Jazi F, Talebi A, Ashrafi F. Gender difference in Cisplatin-induced nephrotoxicity in a rat model: Greater intensity of damage in male than female. Nephrourol Mon 2013;5:818-21.  Back to cited text no. 4
    
5.
Urakami Y, Nakamura N, Takahashi K, Okuda M, Saito H, Hashimoto Y, et al. Gender differences in expression of organic cation transporter OCT2 in rat kidney. FEBS Lett 1999;461:339-42.  Back to cited text no. 5
    
6.
El-Arabey AA. Gender difference in Cisplatin-induced nephrotoxicity in a rat model. Nephrourol Mon 2015;7:e23595.  Back to cited text no. 6
    
7.
Meetam P, Srimaroeng C, Soodvilai S, Chatsudthipong V. Regulatory role of testosterone in organic cation transport: In vivo and in vitro studies. Biol Pharm Bull 2009;32:982-7.  Back to cited text no. 7
    
8.
Rostami B, Nematbakhsh M, Pezeshki Z, Talebi A, Sharifi MR, Moslemi F, et al. Effect of testosterone on cisplatin-induced nephrotoxicity in surgically castrated rats. Eur Arch Otorhinolaryngol 2014;6:5.  Back to cited text no. 8
    
9.
Türk G, Sönmez M, Aydin M, Yüce A, Gür S, Yüksel M, et al. Effects of pomegranate juice consumption on sperm quality, spermatogenic cell density, antioxidant activity and testosterone level in male rats. Clin Nutr 2008;27:289-96.  Back to cited text no. 9
    




 

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