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ORIGINAL ARTICLE
Year : 2017  |  Volume : 8  |  Issue : 1  |  Page : 101

Alloimmunization in thalassemia patients: New insight for healthcare


1 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran; Department of Neurobiology, Care Sciences and Society, H1, Division of Family Medicine, Karolinska Institutet, Huddinge, Sweden
2 Department of Neurobiology, Care Sciences and Society, H1, Division of Family Medicine, Karolinska Institutet, Huddinge, Sweden
3 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
4 Guilan Road Trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran

Correspondence Address:
Ali Davoudi-Kiakalayeh
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpvm.IJPVM_246_16

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Background: Development of alloantibodies against the foreign red blood cell (RBC) (alloimmunization) is a well-known complication in thalassemia patients when performing multiple transfusions. The study was conducted to know the prevalence of alloimmunization in thalassemia patients, in the Caspian Sea coastline. Methods: This study is a descriptive, retrospective analysis of transfusion records of 190 patients with β-thalassemia major who received regular transfusions. To detect the type of alloantibodies, two cells panel tests (kits; Iranian Blood Transfusion Organization [IBTO], 3 RBC cells and IBTO, 11 RBC cells) were used. Results: Forty-seven patients were positive for alloantibodies (24.7%). Of them, 18.4% (35 cases) had only one alloantibody, and 6.3% (12 cases) had at least two or more of alloantibodies. The vast majority of alloantibodies were anti-Kell followed by anti-E, and anti-D, respectively. Conclusions: Blood matching for Rh and K antigens in patients with transfusion-dependent thalassemia could reduce the rate of RBC alloinununization.


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