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ORIGINAL ARTICLE
Year : 2018  |  Volume : 9  |  Issue : 1  |  Page : 57

Novel effects of Rosa damascena extract on patients with neurocognitive disorder and depression: A clinical trial study


1 Department of Anatomical Sciences and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
2 Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
3 Department of Pharmacognosy, The School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
4 Department of Anatomical Sciences, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran
5 Department of Biostatistics, The school of Health, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
6 Department of Pathology, School of Medicine, Kerman University of Medical Sciences, Islamic Republic of Iran

Correspondence Address:
Victoria Omranifard
Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan
Islamic Republic of Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpvm.IJPVM_199_17

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Background: Dementia as a major cognitive neurological disorder is defined as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patient's independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the efficacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia. Methods: This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 2015–2016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and R. damascena capsules, and in control group, placebo capsule instead of R. damascena added on donepezil. Four test was filled three times at the study initiation, after month one and also after month three: Mini–Mental State Examination (MMSE) and Addenbrooke's Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were filled. Results: The results showed add-on donepezil and R. damascena versus placebo improved cognitive impairment based on MMSE with P = 0.002, ACE-R with total P = 0.001, depression (P = 0.012), behavioral disorders (P < 0.001), and daily activity (P < 0.001). Conclusions: The R. damascena extract affected cognitive impairment of dementia patients significantly and also have significant effects on improving depression and behavioral problems.


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