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ORIGINAL ARTICLE
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 135

Advanced parental age and risk of positive autism spectrum disorders screening


1 Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran
2 Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
3 Department of Pediatrics, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
4 Department of Psychiatry, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran

Correspondence Address:
Leila Manzouri
Yasuj University of Medical Sciences, Yasuj
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpvm.IJPVM_25_19

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Background: Autism Spectrum Disorder (ASD) is a life -long neurodevelopmental disorder and significantly influences the quality of life in children. The screening of ASD in children aged between 16-30 months to early detection and early intervention for better prognosis. Methods: This cross-sectional study was conducted in the southwest of Iran (Yasuj) with dominant Lore ethnicity in 2017. A total of 1504 mother- child pairs with children aged between 16-30 months were selected through simple random sampling from the integrated national health system as the framework. ASD screening was implemented using the Modified checklist for autism in toddlers- revised, with follow-up interview (M-CHAT-R/F). Demographic data such as sex of children, and parental age at their time of pregnancy were collected for all children. Results: Risk of ASD was low, moderate and high in 1447 (96.2%), 54 (3.6%) and 3 (0.2%) in screening, respectively. The estimated rate of ASD prevalence was 80 per 10000 (12 out of 1504) or 1 in 125. Mother's age ≥35 (P value = 0.002, OR = 11.65, CI95%: 2.49-54.35) and father's age ≥40 (P value = 0.0001, OR = 19.64, CI95%: 4.89-78.82) were predicting factors of ASD in toddlers aged 16-30 months. Conclusions: Given that, increasing the age of marriage in Iran and recent trend towards delayed childbearing; children born to older parents are at a higher risk for having ASD. So, increasing the public awareness is necessary.


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