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SYSTEMATIC REVIEW
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 213

Effects of selenium supplementation on cardiometabolic risk factors, inflammatory, and antioxidant markers: A systematic review and meta-analysis protocol


1 Deputy of Research and Technology, Ministry of Health and Medical Education; Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2 Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
3 Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
4 Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences; Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5 Spiritual Health Research Center, School of Behavioral Sciences and Mental Health, Tehran Psychiatric Institute, Iran University of Medical Sciences, Tehran, Iran
6 Department of Basic and Clinical Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
7 Social Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
8 Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj; Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
9 Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran
10 Department of Public Health, Maragheh University of medical Sciences, Maragheh, Iran

Correspondence Address:
Hamid Asayesh
Department of Medical Emergencies, Qom University of Medical Sciences, Qom
Iran
Mostafa Qorbani
Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpvm.IJPVM_509_17

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Background: Selenium (Se) is considered as an antioxidant trace element involved in key activities in human metabolism. Recent investigations indicate that Se plays a pivotal role in human health. Se supplementation considered as an intervention is both cost-effective and simple-to-use that may play an important role in the prevention of cardiometabolic risk factors (CRFs), inflammatory, and antioxidant markers. Methods: This paper is a protocol study on systematic review of probable effects of Se supplementation on CRFs, inflammatory, and antioxidant markers. The aim was to achieve three international databases available related to the current publications including, PubMed, ISI/WOS, and Scopus. We attempted to search for randomized clinical trials (RCT) and cross-over trials pertaining to human subjects without any restriction on language and time. In addition, there was no limitation on the age of participants. For RCTs were included all studies in different target groups comprising diabetic patients, patients with polycystic ovarian syndrome, obese subjects, or even healthy controls. To investigate the effect of Se, we included all studies which Se is used either as single therapy or as combination therapy. All studies associated with articles and meta-analyses would be evaluated to review their references. Conclusions: The current study contained numerous outcomes. The result of this study can be led to make reliable scientific evidence on the probable effects of Se supplementation on CRFs, inflammatory factors, and antioxidant factors. In addition to these findings, other technical documents developed for a systematic review can be used for future studies.


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