International Journal of Preventive Medicine

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 6  |  Issue : 1  |  Page : 32-

Cytomegalovirus, toxoplasma gondii and rubella vertical transmission rates according to mid-trimester amniocentesis: A retrospective study


Chrysoula Margioula-Siarkou1, Ioannis Kalogiannidis1, Stamatios Petousis1, Stella Prapa3, Themistoklis Dagklis1, Apostolos Mamopoulos2, Nikos Prapas1, David Rousso2 
1 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki; Iakentro Advanced Medical Center, Thessaloniki, Greece
2 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece

Correspondence Address:
Stamatios Petousis
Falireos 16, 56224 Thessaloniki
Greece

Objective: To examine vertical transmission rates of Cytomegalovirus, Toxoplasma Gondii and Rubella infections according to amniotic fluid PCR analysis. Methods: A retrospective analysis of mid-trimester amniocenteses performed in in pregnancies with diagnosed maternal infection by Cytomegavirus (CMV), Rubella or Toxoplasma gondii during 1994-2008 was performed. Vertical transmission rates were observed according to the presence of the infectious agent«SQ»s DNA in the amniotic fluid. A univariate regression model was also performed to investigate possible correlations between transmission and epidemiological parameters. Results: Overall, 7033 amniocenteses were performed during study«SQ»s period, of which 166 (2.4%) with the indication of maternal infection by CMV, Rubella or Toxoplasma. Mean maternal age was 27.4 ΁ 2.5 years and the mean gestational age at amniocentesis was 18.7 ΁ 2.5 weeks. Vertical transmission was observed in 21 cases (12.7%). Transmission rate was 17.3% in cases with infection from CMV, 9.5% from Toxoplasma gondii and 7.8% from Rubella (P = .05). Maternal age was the only parameter being significantly associated with increased risk for vertical transmission (P = .04). Conclusions: According to our results, overall vertical transmission rate marginally exceeds 10%. CMV infection is characterized by relatively higher transplacental transmission rate, while increased maternal age appears to be associated with a higher risk for vertical transmission


How to cite this article:
Margioula-Siarkou C, Kalogiannidis I, Petousis S, Prapa S, Dagklis T, Mamopoulos A, Prapas N, Rousso D. Cytomegalovirus, toxoplasma gondii and rubella vertical transmission rates according to mid-trimester amniocentesis: A retrospective study.Int J Prev Med 2015;6:32-32


How to cite this URL:
Margioula-Siarkou C, Kalogiannidis I, Petousis S, Prapa S, Dagklis T, Mamopoulos A, Prapas N, Rousso D. Cytomegalovirus, toxoplasma gondii and rubella vertical transmission rates according to mid-trimester amniocentesis: A retrospective study. Int J Prev Med [serial online] 2015 [cited 2019 Oct 15 ];6:32-32
Available from: http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=32;epage=32;aulast=Margioula-Siarkou;type=0