International Journal of Preventive Medicine

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 1  |  Page : 18-

Effects of levothyroxine on visual evoked potential impairment following local injections of lysolecithin into the rat optic chiasm


Cobra Payghani1, Fatemeh Khani1, Aryan Rafieezadeh1, Parham Reisi1, Hojjatallah Alaei1, Bahman Rashidi2 
1 Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence Address:
Parham Reisi
Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system which has no any known definitive treatment. Studies have shown that thyroid hormones (THs) in addition to their roles in the development of the nervous system and the production of myelin have important roles in the adult's brain function. Since the only way to treat MS is the restoration of myelin, the aim of this study was to evaluate the effects of levothyroxine on visual evoked potential (VEP) impairment following local injections of lysolecithin into the rat optic chiasm. Methods: To induce demyelination, lysolecithin was injected into the optic chiasm of male Wistar rats. VEP recording was used to evaluate demyelination and remyelination before and 10, 17, and 24 days after the lysolecithin injection. The rats received an intraperitoneal injection of levothyroxine with doses 20, 50, and 100 μg/kg in different experimental groups. Results: VEP latency and amplitude showed demyelination at 10 and 17 days after an induced lesion in MS group which was reversed at day 24. Levothyroxine prevented these impairments, especially in high doses. Conclusions: According to the results, lysolecithin-induced demyelination at optic chiasm and VEP impairments can be restored by administration of levothyroxine. Therefore, THs probably have positive effects in demyelinating diseases.


How to cite this article:
Payghani C, Khani F, Rafieezadeh A, Reisi P, Alaei H, Rashidi B. Effects of levothyroxine on visual evoked potential impairment following local injections of lysolecithin into the rat optic chiasm.Int J Prev Med 2018;9:18-18


How to cite this URL:
Payghani C, Khani F, Rafieezadeh A, Reisi P, Alaei H, Rashidi B. Effects of levothyroxine on visual evoked potential impairment following local injections of lysolecithin into the rat optic chiasm. Int J Prev Med [serial online] 2018 [cited 2020 Apr 3 ];9:18-18
Available from: http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2018;volume=9;issue=1;spage=18;epage=18;aulast=Payghani;type=0