International Journal of Preventive Medicine

REVIEW ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 14-

Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Clinical Trials


Mitra Hariri1, Sara Zohdi2 
1 Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran
2 Student Research Committee, Neyshabur University of Medical Sciences, Neyshabur, Iran

Correspondence Address:
Mitra Hariri
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur
Iran

New evidence suggests that low serum Vitamin D may cause nonalcoholic fatty liver disease (NAFLD). Hypovitaminosis D is associated with the severity and incidence of NAFLD. The objective of this study was to conduct a systematic review on randomized controlled trials (RCTs) assessing the effect of Vitamin D on serum metabolic profile among NAFLD patients. Databases including PubMed, Institute for Scientific Information Web of Science, Scopus, and Google Scholar were searched up to November 2016. RCTs which studied Vitamin D effect on metabolic profiles and liver function, and conducted among adults were included. Six articles were eligible to be considered in this systematic review. According to the result, Vitamin D supplementation might improve lipid profile and inflammatory mediators when compared with placebo. No article indicated significant effect of Vitamin D on liver enzymes except one article which revealed that Vitamin D together with calcium carbonate can reduce liver enzymes. Vitamin D supplementation may not improve anthropometric measures and glycemic index variables among patients with NAFLD. Vitamin D supplement might improve NAFLD symptoms, especially inflammatory mediators. More RCTs in different parts of world with different forms and doses of Vitamin D are necessary.


How to cite this article:
Hariri M, Zohdi S. Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Clinical Trials.Int J Prev Med 2019;10:14-14


How to cite this URL:
Hariri M, Zohdi S. Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease: A Systematic Review of Randomized Controlled Clinical Trials. Int J Prev Med [serial online] 2019 [cited 2020 Aug 8 ];10:14-14
Available from: http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=14;epage=14;aulast=Hariri;type=0