International Journal of Preventive Medicine

: 2019  |  Volume : 10  |  Issue : 1  |  Page : 90-

Alloimmunization in thalassemia patients

Beuy Joob1, Viroj Wiwanitkit2,  
1 Sanitation Medical Academic Center, Bangkok, Thailand
2 Department of Tropical Medicine, Hainan Medical University, Haikou, China; Department of Biological Science, Joseph Ayo Babalola University, Osun State, Nigeria

Correspondence Address:
Beuy Joob
Sanitation 1 Medical Academic Center, Bangkok

How to cite this article:
Joob B, Wiwanitkit V. Alloimmunization in thalassemia patients.Int J Prev Med 2019;10:90-90

How to cite this URL:
Joob B, Wiwanitkit V. Alloimmunization in thalassemia patients. Int J Prev Med [serial online] 2019 [cited 2020 Jul 8 ];10:90-90
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Dear Editor,

We read the publication on “Alloimmunization in thalassemia patients” with a great interest. Davoudi-Kiakalayeh et al. concluded that “blood matching for Rh and K antigens in patients with transfusion-dependent thalassemia could reduce the rate of red blood cell alloimmunization.”[1] We would like to share ideas and experience from our setting in Indochina where the prevalence of transfusion-dependent thalassemia is very high. In our setting, the blood matching for Rh and K antigens is routinely done in big blood bank centers. Nevertheless, the high rate of alloimmunization among the patients is still observed.[2] The problem might be due to the limitation of the availability of minor blood group matching feasibility among small blood banks in remote areas where many thalassemia patients live. According to a recent report by Jansuwan et al., it was found that “splenectomy is associated with increased alloantibody formation.”[2] It might be an additional clue that there is a requirement for special minor blood group matching for the thalassemia patients with postsplenectomy status.

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1Davoudi-Kiakalayeh A, Mohammadi R, Pourfathollah AA, Siery Z, Davoudi-Kiakalayeh S. Alloimmunization in thalassemia patients: New insight for healthcare. Int J Prev Med 2017;8:101.
2Jansuwan S, Tangvarasittichai O, Tangvarasittichai S. Alloimmunization to red cells and the association of alloantibodies formation with splenectomy among transfusion-dependent β-thalassemia major/HbE patients. Indian J Clin Biochem 2015;30:198-203.