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  Indian J Med Microbiol
 

Figure 1: Angiotensin-converting enzyme 2 (ACE2) causes the production of angiotensin (1-7) Ang-(1-7) from angiotensin-2 (AngII). Ang (1-7) causes the production of Mas protein, which leads to the formation of brain-derived neurotrophic factor (BDNF), as the main protein in neurogenesis, and inhibits occurrences of oxidative stress, inflammation and apoptosis and also cause modulation of the mood-related disorder. Ang (1-7) causes activation of AT2R, which is angiotensin receptor type-2. Activation of AT2R plays a critical role in the management of the normal function of brain vascular endothelial. According to some indirect evidence, it seems the infection by the COVID-19 virus can cause distributing ACE-2/Mas/BDNF signaling pathway and can have unknown neurological and mental sequels. eNOS: Endothelial-derived nitric oxide syntheses; NO: Nitric oxide; MDA: Malondialdehyde; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; GR: Glutathione reductase; TNF-α: Tumor necrosis factor-alpha; IL-1β: Interleukin 1-β

Figure 1: Angiotensin-converting enzyme 2 (ACE2) causes the production of angiotensin (1-7) Ang-(1-7) from angiotensin-2 (AngII). Ang (1-7) causes the production of Mas protein, which leads to the formation of brain-derived neurotrophic factor (BDNF), as the main protein in neurogenesis, and inhibits occurrences of oxidative stress, inflammation and apoptosis and also cause modulation of the mood-related disorder. Ang (1-7) causes activation of AT<sub>2</sub>R, which is angiotensin receptor type-2. Activation of AT<sub>2</sub>R plays a critical role in the management of the normal function of brain vascular endothelial. According to some indirect evidence, it seems the infection by the COVID-19 virus can cause  distributing ACE-2/Mas/BDNF signaling pathway and can have unknown neurological and mental sequels. eNOS: Endothelial-derived nitric oxide syntheses; NO: Nitric oxide; MDA: Malondialdehyde; SOD: Superoxide dismutase; GPx: Glutathione peroxidase; GR: Glutathione reductase; TNF-α: Tumor necrosis factor-alpha; IL-1β:  Interleukin 1-β