| ORIGINAL ARTICLE |
|
| Year : 2015 | Volume
: 6
| Issue : 1 | Page : 32 |
|
|
Cytomegalovirus, toxoplasma gondii and rubella vertical transmission rates according to mid-trimester amniocentesis: A retrospective study
Chrysoula Margioula-Siarkou1, Ioannis Kalogiannidis1, Stamatios Petousis1, Stella Prapa2, Themistoklis Dagklis1, Apostolos Mamopoulos3, Nikos Prapas1, David Rousso3
1 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki; Iakentro Advanced Medical Center, Thessaloniki, Greece
2 Iakentro Advanced Medical Center, Thessaloniki, Greece
3 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Correspondence Address:
Stamatios Petousis
Falireos 16, 56224 Thessaloniki
Greece
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2008-7802.154774
|
|
|
Objective: To examine vertical transmission rates of Cytomegalovirus, Toxoplasma Gondii and Rubella infections according to amniotic fluid PCR analysis.
Methods: A retrospective analysis of mid-trimester amniocenteses performed in in pregnancies with diagnosed maternal infection by Cytomegavirus (CMV), Rubella or Toxoplasma gondii during 1994-2008 was performed. Vertical transmission rates were observed according to the presence of the infectious agent's DNA in the amniotic fluid. A univariate regression model was also performed to investigate possible correlations between transmission and epidemiological parameters.
Results: Overall, 7033 amniocenteses were performed during study's period, of which 166 (2.4%) with the indication of maternal infection by CMV, Rubella or Toxoplasma. Mean maternal age was 27.4 2.5 years and the mean gestational age at amniocentesis was 18.7 2.5 weeks. Vertical transmission was observed in 21 cases (12.7%). Transmission rate was 17.3% in cases with infection from CMV, 9.5% from Toxoplasma gondii and 7.8% from Rubella (P = .05). Maternal age was the only parameter being significantly associated with increased risk for vertical transmission (P = .04).
Conclusions: According to our results, overall vertical transmission rate marginally exceeds 10%. CMV infection is characterized by relatively higher transplacental transmission rate, while increased maternal age appears to be associated with a higher risk for vertical transmission |
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
