|LETTER TO EDITOR
|Year : 2015 | Volume
| Issue : 1 | Page : 47
Comment on: Pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats
Amr Ahmed EL-Arabey
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo, Egypt
|Date of Submission||13-Apr-2015|
|Date of Acceptance||21-Apr-2015|
|Date of Web Publication||04-Jun-2015|
Amr Ahmed EL-Arabey
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al Azhar University, Nasr City, Cairo
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
EL-Arabey AA. Comment on: Pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats. Int J Prev Med 2015;6:47
I read with interest a recently published article in the "International Journal Prevention Medicine" by Jilanchi et al., entitled "Pomegranate flower extract does not prevent cisplatin-induced nephrotoxicity in female rats."  The authors have concluded that administration of pomegranate flower extract not only did not ameliorate nephrotoxicity induced by cisplatin (CP) in female rats, but also aggravated renal damage.  Here, I would like to explain the potential mechanism may be related to this effect. Pomegranate contains phytoestrogens, which are protective nonsteroidal plant chemicals, some of which structurally resemble endogenous estrogens from humans and animals.  Phytoestrogens have estrogenic activity due to their structural resemblance to diethylstilbestrol, a synthetic estrogen.  A recent study demonstrated that fennel essential oil (FEO) has not protective role against CP-induced nephrotoxicity; they attributed that the major component of FEO is trans-anethole that has estrogenic activity. , The pharmacological doses of estrogen could abolish the nephroprotectant effect of some proven antioxidants which reduce the changes caused due to CP.  Moreover, estrogen is not a nephroprotectant in CP-induced nephrotoxicity in ovariectomized rats.  Furthermore, a recent study demonstrated that estrogen has a suppressive effect on erythropoietin induction, leading to the deceleration of erythropoiesis.  In addition, studies showed that estrogen increases oxidative stress in kidney  and promotes kidney toxicity in proximal tubules.  Finally, I suggest PEF contains phytoestrogens, which have estrogenic activity. Hence, PEF does not prevent CP-induced nephrotoxicity in female rats.
| References|| |
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