• Users Online: 4836
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Browse Articles Search Archives Submit article Instructions Subscribe Contacts Login 

 Table of Contents  
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 39

Bivariate spatio-temporal shared component modeling: Mapping of relative death risk due to colorectal and stomach cancers in Iran provinces

1 Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Biostatistics, School of Public Health, Kermanshah University of Medical Sciences, Isfahan, Iran

Date of Submission08-Feb-2017
Date of Acceptance30-Oct-2017
Date of Web Publication15-Mar-2019

Correspondence Address:
Behzad Mahaki
Department of Biostatistics, School of Health, Kermanshah University of Medical, Kermanshah
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.IJPVM_31_17

Rights and Permissions

Background: Gastrointestinal cancers make for nearly half fatal cancers with colorectal and stomach cancers' being listed among the ten most common in Iran. This research aims to determine the spatial pattern and temporal trend of death risk due to colorectal and stomach cancers among provinces of Iran and estimate the effect of shared and specific components as surrogates of risk factors for the aforementioned cancers on changes of death due to the cancers over time and place. Methods: In this ecological study, the data regarding death causes in colorectal and stomach cancers during 2006–2011 were obtained from the death registration system of the Iranian Ministry of Health. The estimation of relative risk (RR) of death due to the target cancers was performed applying Bayesian spatiotemporal shared component (SC) model in OpenBUGS software. Results: North-Western provinces ranked first regarding stomach cancer RR of death (RR >1.75). Furthermore, some North-Western and central provinces had the highest RR of death due to colorectal cancer (RR >1.5). The SC surrogating the risk factor shared between both cancers had the most effect in Northern, North-Western and western provinces, and the least effect in Southern and South-Eastern ones. Conclusions: North and North-West of Iran found to be the high-risk area for death due to both stomach and colorectal cancers and South-East and South provinces shown to have the lowest RR. The obtained results can be illuminating to health resource allocation to the health policymakers.

Keywords: Bayesian model, colorectal cancer, disease mapping, model, shared component, stomach cancer

How to cite this article:
Ahmadipanahmehrabadi V, Hassanzadeh A, Mahaki B. Bivariate spatio-temporal shared component modeling: Mapping of relative death risk due to colorectal and stomach cancers in Iran provinces. Int J Prev Med 2019;10:39

How to cite this URL:
Ahmadipanahmehrabadi V, Hassanzadeh A, Mahaki B. Bivariate spatio-temporal shared component modeling: Mapping of relative death risk due to colorectal and stomach cancers in Iran provinces. Int J Prev Med [serial online] 2019 [cited 2023 Feb 4];10:39. Available from: https://www.ijpvmjournal.net/text.asp?2019/10/1/39/254187

  Introduction Top

Cancer is one of the most important death causes around the world. According to the declaration of the World Health Organization, more than 13 million people will die due to cancer in 2030.[1] Cancer is the third cause of mortality after car accident and cardiovascular disease in Iran, so cancer is an important problem in public health in Iran.[2] Gastrointestinal cancers make for nearly half of fatal cancers[3] with colorectal and stomach cancers as examples. According to the estimations of International Agency for Research on Cancer, stomach cancer was the fifth most common cancer and the third main death cause in 2012.[4] Geographical distribution has shown to have no pattern; for instance in Asia, along with high-risk countries such as Japan, Korea, and China, there stands the very low-risk India. This may due to different factors such as age, food culture, race but does not follow a strict geographical pattern.[5],[6] As stated by 2008–2009 report of Cancer Registry System in Iran, stomach cancer is the third most common cancer in Iran, which happens to be more occurring in the northern parts of the country.[3] It, as well, was a cause of 15.5 percent of deaths in Iran in 2012 and has been the deadliest cancer.[4]

Colorectal cancer is the third most fatal after lung and stomach cancers[7] and in Iran, it ranks as the third and fourth cause of death in men and women, respectively.[8] Iran's Cancer Registry System indicates that the disease occurrences are more frequent in the northern provinces, compared to the central and southern ones.[9] Regarding the soaring rate of occurrences of cancer in Iran and the distribution of the occurrences in differing provinces, as well as the pressing importance of prevention regarding the disease, recognition and identification of the risk factors along with the high-risk geographical regions seem to be inevitable.

The important role geographical distribution of disease scales play in identifying the relative risk (RR) factors has led to intensive use of spatial statistics tools (a branch of Statistics for analyzing spatial data) in performing the analysis.[10] Disease mapping is an example, which is defined as a collection of statistic methods to obtain exact estimations of occurrence, prevalence or death rates of the disease and organizing them in the form of geographical maps.[11]

Since in numerous studies in Medicine and Hygiene, Preventive Medicine and Epidemiology, data is obtained in temporal courses over some years, it is only logical to take into account the analysis of disease mapping which include the time aspect. Doing so, the available spatial models have expanded to different spatiotemporal models.[12],[13],[14],[15] The advantages of spatiotemporal modeling over pure spatial analysis approach is the fact that the former makes it possible to simultaneously investigate the trends over a course of time and single out the uncommon trends. Spatial patterns of diseases risks with fixed or increasing trends over time, provide more convincing clues compared to analysis of spatial patterns in a specific point in time.[16]

To date, the major part of cancer research body in Iran has been descriptive while very few has ever glanced over the role of risk factors. There were a few studies maneuvering over joint cancer mapping in Iran. However, none of these studies used joint spatiotemporal modeling.[17],[18],[19],[20],[21],[22]

Recent years have seen more and more cases of cancer occurrence and the distribution seems to be geographically-bound in different parts of the country. Considering the shared risk factors between colorectal and stomach cancers and the fact that the very limited body of research regarding cancer mortality in Iran is purely descriptive and solely touches death rates in a specific region over a single time course, the researchers decided to implement bivariate spatiotemporal shared component (SC) modeling to investigate shared and distinct temporal and spatial death causes regarding the two cancers.

  Methods Top

Study design and data

The present ecological study used the data for death due to colorectal and stomach cancers in all provinces in Iran except for Tehran province from 2006 to 2011 with no regard to the cases' age, gender, etc. The researchers obtained the required data from death and cause of death registration system of the Iranian Ministry of Health. The Ethical Committee of Isfahan University of Medical Sciences, in Isfahan, Iran approved the current study (Project number: 395002).

Here, Yijk indicates the number of deaths due to kth cancer (k = 1, 2) in the ith region (i = 1,…, 29) and jth temporal course (j = 1,…, 6) while Eijk indicates the expected death record due to each of the aforementioned cancers which is reached by multiplying the kth death probability of target cancer into jth year into the population of the ith province during the jth year. The provinces' populations were estimated based on the national census of 2006 reported by the Iran Statistical Center. The annual population growth trend of each province was used to estimate the population in the years 2007–2011. The country's incidence of the death due to the kth cancer was obtained through dividing the number of deaths due to that specific cancer during the desired period of time across the country by the country's population.

Statistical analysis

We implemented joint spatiotemporal mapping using bivariate spatiotemporal SC model.[16] In addition to entering the time dimension, spatiotemporal interaction effects and spatial correlated heterogeneities were also added to the model and four bivariate spatiotemporal mapping models were introduced. The models differed in whether or not to enter the spatiotemporal interaction and heterogeneity value.

The models were performed in Bayesian modeling framework. First, it was assumed that the number of deaths due to kth cancer, in the ith region, during the jth temporal course complies with Poisson distribution Yijk~poisson (θijkEijk) where stands for unknown relative death risk of kth cancer in the ith region during the jth temporal course.

Second, the latent variables (SCs) were introduced and variability of observed distribution around unknown RRs (θijk) were modeled. The spatiotemporal structure was introduced based on modeling log of RR.

Among the four mentioned models, for the sake of parsimony, only the most complex model consisting of all parameters, intercepts, spatial and temporal shared and specific components along with their scale parameters, spatiotemporal interaction effects, and heterogeneity effects is introduced here:

Here, θij1,θij2 are respectively expressing the RR of death due to stomach and colorectal cancers in the ith province, during the jth temporal course.

αk indicates disease-specific intercept of the kth cancer while λi, λ1i, λ2i and tj, t1j, t2j respectively refer to the spatial and temporal effects of shared and specific components suggesting the risk factors of the specific cancer.

Spatial and temporal scale parameters (δ > 0,ψ > 0) respectively indicate the weight of SCs on spatial and temporal changes of the cancers and can be different for each of related cancers.

Finally, ξij is the space-time interaction effect and ξijk indicates the heterogeneity effects.

To perfect the Bayesian model, all unknown parameters were assigned prior distribution. The random spatial effects (λi, λ1i, λ2i) were assigned normal conditional autoregressive prior distribution with weights equal 1 to the neighboring regions, where adjacency matrix is defined according to this neighboring structure. Accordingly, first order random walk priors were implemented for temporal trends (tj, t1j, t2j).[12],[16] For space-time interaction effects ξij, simple interchangeable hierarchical structures for were taken into consideration.[14] For heterogeneity expression (ξij1, ξij2)2 multivariate normal distribution was assigned with mean of zero Σ-1 and covariance matrix. Flat noninformative distribution was also assigned to disease-specific intercepts(αk). A normal distribution was, as well, assigned to the logarithm of temporal and spatial scale parameters (logδ and logψ). The hyper-parameters of shared elements (τ's) were separately assigned the weakly informative Gamma hyperprior distributions.[23] For the precision matrix of disease-specific heterogeneity effects (Σ-1), Wishart prior distribution (Q, 2) was used, where Q is the 2-dimensional identity matrix (I2).

The suitability of all models to the data was assessed through Bayesian estimation software, OpenBUGS. Posterior distribution estimations for the model parameters were obtained from simulation methods of Monte Carlo Markov Chain. Markov chain was administered 50,000 times for each model and Brooks-Gelman-Rubin diagnostic tool, as well as observing the autocorrelation figures were implemented to assess the convergence of all parameters. Burn-in was repeated 20,000 times and the results were reported based on the remaining 30,000 posterior sample with thin 10 to decrease correlation.[24],[25] The comparison between the spatiotemporal models SC was done using deviance information criterion (DIC) where the lower values indicated the model's being more suitable.[23],[24],[26],[27]

  Results Top

[Table 1] includes the death due to stomach and colorectal cancers from 2006 to 2011, based on the information obtained from the death causes registration and classification system in the Iranian Ministry of Health and Medical Education. This indicates that, in spite of minor fluctuations in some years, the number of the deceased due to the two aforementioned cancers has increased in the country.
Table 1: The number of the deceased due to stomach and colorectal cancers from 2006 to 2011

Click here to view

As mentioned earlier, this study was designed to investigate 4 forms of SC bivariate spatiotemporal models, based on having or not having the spatiotemporal interaction effects as well as the disease-specific heterogeneity effects. To compare the suitability of the 4 main models and to choose the optimized model, the DIC was used and the related information can be found in [Table 2].
Table 2: The results of deviance information criterion to compare bivariate spatiotemporal shared component models

Click here to view

As shown in [Table 2], the model with disease-specific heterogeneity effect which does not have the spatiotemporal interaction effect (Model 3) is the best and thus chosen for the modeling.

Then, the RR of death due to stomach and colorectal cancers was estimated using the bivariate spatiotemporal SC model [Figure 1] and [Figure 2]. It indicated that stomach cancer is of higher relative death risk in Northern, North-Western and western provinces. Southern, South-Eastern and South-Western provinces were of the lowest risk in all 5 temporal periods. Some North-Western and central provinces found to have the highest relative death risk due to colorectal cancer in all 5 temporal periods.
Figure 1: The map of estimated relative death risk due to stomach cancer according to bivariate spatiotemporal shared component model: 2006–2011

Click here to view
Figure 2: The map of estimated relative death risk due to colorectal cancer according to bivariate spatiotemporal shared component model: 2006–2011

Click here to view

Then, the estimation map of RR of the effect of SCs of risk factors was designed based on spatial distribution of each cancer across the temporal course (λi, λ1i, λ2i) [Figure 3]. The values indicate the effect of each component surrogating the risk factors on the geographical distribution of RR due to the cancers' death cause related in all investigated temporal courses. The SC surrogating the risk factor shared between stomach and colorectal cancers had the most dominant effect in Northern, North-Western and western provinces, and the least dominant effect in Southern and South-Eastern ones [Figure 3]A. Generally speaking, the map of effect of stomach cancer specific component has almost always been steady and a specific pattern cannot be traced among the effects of this component across provinces [Figure 3]B. The pattern noticed regarding the colorectal cancer-specific component effect, on the other hand, is a bit different. This specific component has the highest effect in Yazd (center of country), Semnan (center), and East-Azerbaijan (North-West) and the least effect in two central provinces, Kohgiluyeh and Boyerahmad, and Chaharmahal and Bakhtiyari provinces [Figure 3]C.
Figure 3: The map of estimated relative risk of spatial effect of shared and specific components based on bivariate spatiotemporal shared component model

Click here to view

[Table 3] shows the estimate of RR of the temporal effect of the components across the country. All the obtained values are similar and really close to 1 and all the intervals include 1. This shows that the effects of the components representing the risk factors on the temporal trend of relative death risk due to the cancers is not meaningful. This indicates that as the time progresses, RRs are not decreasing or increasing for.
Table 3: The estimated relative risk of temporal effects of shared and specific components: Posterior median (95% CI) per year

Click here to view

The relative weight of these effects was estimated, so that the role of the components in spatial changes of the related cancers could be compared more precisely. 1.27 indicates the ratio between the magnitudes of SC for stomach and colorectal cancers and reveals that the role of shared risk factor in geographical distribution of death due to stomach cancer plays is more pervasive compared to that of colorectal cancer but the value interval (0.590–-3.086) which, as well, includes 1, indicates that the relative magnitude of SC in spatial changes of the two cancers is not meaningful.

To better compare the magnitude of temporal effects of risk factor components in related cancers, the relative magnitude of these effects was estimated. The estimations talk of the magnitude of risk factors in changes of deaths due to the relevant cancers across the studied regions, during the temporal period. The results showed that the ratio of weight of SC for stomach cancer to the same weight for colorectal cancer in 0.935 with value interval of (0.475–1.809) which, in turn, indicates that the relative weight of SC s of temporal changes in both cancers is not meaningful.

  Discussion and Conclusions Top

Bivariate spatiotemporal SC model is a latent-variable model which does not need real data on risk factors. By entering the components as surrogates of risk factors, the model can clarify not only the spatial pattern and temporal trend of investigated diseases, but also the spatial and temporal effects of these components as well as the relative weight of temporal and spatial effects of the components on each of the related diseases.[10],[23],[24],[28],[29]

In this study, we applied the mentioned model in Iran for the first time. The previous studies in the field of joint disease mapping in Iran does not take time effect into account and there were not possible to evaluate temporal trend of disease and their risk factors.[18]

In addition to its superiority over the pure spatial models, this model has some advantages over other multivariate spatiotemporal disease mapping models: The possibility to separately estimate of shared and specific components as surrogates of risk factors, while other models only map the general RR of each disease; the expanded possibility to recognize the high risk regions; having temporal and spatial scale parameters and so estimating the relative weight of each SC for all related disease; the possibility to have spatial-temporal, spatial-disease, temporal-disease, and spatial-temporal-disease interaction effects; no need to limiting constraint of considering the similar correlation between the diseases across all regions.[16],[30]

Applying this model needs for the number of risk factors and the disease linked to each risk factor in advance. The final results would highly depend on the way the risk factors are defined. To identify the related risk factors of each disease, the epidemiological history of diseases need to be taken into consideration.[13],[29]

In this model, it is assumed that effects of shared and specific components are independent from one another. This assumption is not constant in many of the observations and epidemiologic documents.[29],[31],[32]

Compared to raw mapping or mapping standardized values, this model has proved to be more efficient when the number of desired observed cases is rare. Hence, the higher the level of access to information such as the counties, cities, urban areas, and postal areas, the more efficient the model will be.

We found that two South-Eastern and Southern provinces, Sistan and Baluchistan and Hormozgan have lowest RR for both cancers. Northe and North-West part of country including Mazandaran, East-Azerbaijan, and Kurdistan are the highest risk areas regarding the two stomach and colorectal cancers and these obtained results are consistent with those of Mahaki et al.,[17] Kavousi et al.,[33] Rastaghi et al.[34] and Nasrazadani et al.[35]

This study has some limitations:

  1. We only have five short time periods in this study. As a result we found that there is not any significant temporal effect of the shared and specific components across the country. This is because cancers are long latency chronic diseases and so we do not expect “bursts” of short-term clusters
  2. Data were available only for provincial level and not for counties, districts, etc., so we had to consider the provinces as our geographical areas
  3. As age and sex information was not available, we did not used age-standardized rates of deaths and data for each sex separately. This is a major limitation of the study
  4. In addition to age and sex, we did not have access to data about other risk factors of the cancers or death due to. Hence, the model does not contain any covariates
  5. We used the prior distributions only based on suggestion from the published papers.

Based on the results and the mentioned limitation, there are some suggestions:

It is suggested that this model be implemented for longer time period to better evaluate the temporal trend. In addition, having smaller regions such as counties, towns, areas or neighborhoods helps showing the advantages of the model over mapping raw data. It is recommended to adjust for age, sex, and the most known factors affecting the incidence and death rates of the cancer to make the results more interpretable.

It is also suggested sensitivity analysis for different prior distributions be taken in to consideration and the results of the distributions be compared. This will help to estimate the sensitivity of the model to the prior distributions allocated to the parameters. Finally, this study provides useful information, on areas requiring more attention, for policy makers and medical experts. It is seen fit to perform more epidemiological studies in high risk regions, so that prevention policies are grounded in such high risk areas.[36]

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

World Health Organization. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Lyon, France: International Agency for Research on Cancer; 2012. Available from: http://www.globocan.iarc.fr. [Last accessed on 2017 Jun 30].  Back to cited text no. 1
Mahaki B, Mehrabi Y, Kavousi A, Schmid VJ, Joint spatio-temporal shared component model with an application in iran cancer data. Asian Pac J Cancer Prev 2018:19:1553-60.  Back to cited text no. 2
Irainain Cancer Report. Irianian Annual of National Cancer Registration Report, Islamic Republic of Iran-2009. Ministry of Health and Medical Education, Deputy for Health Center for Diseases Control & Management Tehran; 2012.  Back to cited text no. 3
Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 Vl. 0, Cancer Incidence and Mortality Worldwide: IARC Cancer Base No 11. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://www.globocan.iarc.fr. [Last accessed on 2016 Nov 30].  Back to cited text no. 4
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ, et al. Cancer statistics, 2009. CA Cancer J Clin 2009;59:225-49.  Back to cited text no. 5
Fuccio L, Eusebi LH, Bazzoli F. Gastric cancer, helicobacter pylori infection and other risk factors. World J Gastrointest Oncol 2010;2:342-7.  Back to cited text no. 6
World Health Organization. Cancer. J Basic Res Med Sci 2009;14:341-8.  Back to cited text no. 7
Sadjadi A, Nouraie M, Mohagheghi MA, Mousavi-Jarrahi A, Malekezadeh R, Parkin DM, et al. Cancer occurrence in Iran in 2002, an international perspective. Asian Pac J Cancer Prev 2005;6:359-63.  Back to cited text no. 8
Khedri A, Nejat-Shokouhi A, Salek R, Esmaeili H, Mokhtarifar A, Entezari Heravi R, et al. Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population. Mol Biol Rep 2011;38:2939-43.  Back to cited text no. 9
Knorr-Held L, Best NG. A shared component model for detecting joint and selective clustering of two diseases. J R Stat Soc 2001;164:73-85.  Back to cited text no. 10
Mehrabi Y, Maraghi E, Alavi Majd H, Motlagh M. Mapping relative risk of infant mortality in Iranian rural areas in years 2001 and 2006: Comparison of maximum likelihood and bayesian methods. Iran J Epidemiol 2010;6:1-7.  Back to cited text no. 11
Oleson JJ, Smith BJ, Kim H. Joint spatio-temporal modeling of low incidence cancers sharing common risk factors. J Data Sci 2008;6:105-23.  Back to cited text no. 12
Knorr-Held L, Besag J. Modelling risk from a disease in time and space. Stat Med 1998;17:2045-60.  Back to cited text no. 13
Knorr-Held L. Bayesian modelling of inseparable space-time variation in disease risk. Stat Med 2000;19:2555-67.  Back to cited text no. 14
Bernardinelli L, Clayton D, Pascutto C, Montomoli C, Ghislandi M, Songini M, et al. Bayesian analysis of space-time variation in disease risk. Stat Med 1995;14:2433-43.  Back to cited text no. 15
Richardson S, Abellan JJ, Best N. Bayesian spatio-temporal analysis of joint patterns of male and female lung cancer risks in Yorkshire (UK). Stat Methods Med Res 2006;15:385-407.  Back to cited text no. 16
Raei M, Schmid VJ, Mahaki B. Bivariate spatiotemporal disease mapping of cancer of the breast and cervix uteri among Iranian women. Geospatial Health 2018:13:164-71.  Back to cited text no. 17
Chamanpara P, Moghimbeigi A, Faradmal J, Poorolajal J. Joint disease mapping of two digestive cancers in golestan province, Iran using a shared component model. Osong Public Health Res Perspect 2015;6:205-10.  Back to cited text no. 18
Rastaghi S, Jafari-Koshki T, Mahaki B. Application of Bayesian multilevel space-time models to study relative risk of esophageal cancer in Iran 2005-2007 at a county level. Asian Pac J Cancer Prev 2015;16:5787-92.  Back to cited text no. 19
Haddad-Khoshkar A, Jafari-Koshki T, Mahaki B. Investigating the incidence of prostate cancer in Iran 2005-2008 using Bayesian spatial ecological regression models. Asian Pac J Cancer Prev 2015;16:5917-21.  Back to cited text no. 20
Jafari-Koshki T, Arsang-Jang S, Mahaki B. Bladder cancer in Iran: Geographical distribution and risk factors. Int J Cancer Manag 2017;10:e5610. doi: 10.5812/ijcp.5610.  Back to cited text no. 21
Khoshkar AH, Koshki TJ, Mahaki B. Comparison of Bayesian spatial ecological regression models for investigating the incidence of breast cancer in Iran, 2005- 2008. Asian Pac J Cancer Prev 2015;16:5669-73.  Back to cited text no. 22
Dabney AR, Wakefield JC. Issues in the mapping of two diseases. Stat Methods Med Res 2005;14:83-112.  Back to cited text no. 23
Dreassi E. Polytomous disease mapping to detect uncommon risk factors for related diseases. Biom J 2007;49:520-9.  Back to cited text no. 24
Gimenez O, Bonner SJ, King R, Parker RA, Brooks SP, Jamieson LE, et al. WinBUGS for population ecologists: Bayesian modeling using Markov Chain Monte Carlo methods. Modeling Demographic Processes in Marked Populations. New York, US: Springer; 2009. p. 883-915.  Back to cited text no. 25
Spiegelhalter DJ, Best NG, Carlin BP, Van Der Linde A. Bayesian measures of model complexity and fit. J R Stat Soc 2002;64:583-639.  Back to cited text no. 26
Celeux G, Forbes F, Robert CP, Titterington DM. Deviance information criteria for missing data models. Bayesian Anal 2006;1:651-73.  Back to cited text no. 27
Downing A, Forman D, Gilthorpe MS, Edwards KL, Manda SO. Joint disease mapping using six cancers in the Yorkshire region of England. Int J Health Geogr 2008;7:41.  Back to cited text no. 28
Best N, Hansell AL. Geographic variations in risk: Adjusting for unmeasured confounders through joint modeling of multiple diseases. Epidemiology 2009;20:400-10.  Back to cited text no. 29
Manda SO, Feltbower RG, Gilthorpe MS. Investigating spatio-temporal similarities in the epidemiology of childhood leukaemia and diabetes. Eur J Epidemiol 2009;24:743-52.  Back to cited text no. 30
Leyland AH, Langford IH, Rasbash J, Goldstein H. Multivariate spatial models for event data. Stat Med 2000;19:2469-78.  Back to cited text no. 31
Montazeri A, Sadighi J, Farzadi F, Maftoon F, Vahdaninia M, Ansari M, et al. Weight, height, body mass index and risk of breast cancer in postmenopausal women: A case-control study. BMC Cancer 2008;8:278.  Back to cited text no. 32
Kavousi A, Bashiri Y, Mehrabi Y, Etemad K. Modeling high-risk areas for gastric cancer in men and women, 2005-2009. J Isfahan Med Sch 2015;33:82-92.  Back to cited text no. 33
Rastaghi S, Jafari-Koshki T, Mahaki B, Bashiri Y, Mehrabani K, Soleimani A, Trends and risk factors of Gastric Cancer in Iran (2005-2010). Int J Prev Med. doi: 10.4103/ijpvm.IJPVM_188_17 [In Press].  Back to cited text no. 34
Nasrazadani M, Maracy MR, Mahaki B. Mapping of stomach, colorectal and bladder cancers in Iran, 2004-2009: Applying Bayesian Polytomous Logit model. Int J Prev Med. doi:10.4103/ijpvm.IJPVM_30_17. [In Press].  Back to cited text no. 35
[PUBMED]  [Full text]  
Jafari-Koshki T, Arsang-Jang S, Mahaki B. Bladder cancer in Iran: Geographical distribution and risk factors. Iran J Cancer Prev 2017;10.  Back to cited text no. 36


  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2], [Table 3]

This article has been cited by

Epidemiologic Study of Gastric Cancer in Iran: A Systematic Review

Khadijeh Kalan Farmanfarma,Neda Mahdavifar,Soheil Hassanipour,Hamid Salehiniya
Clinical and Experimental Gastroenterology. 2020; Volume 13: 511
[Pubmed] | [DOI]
2 Time series analysis of monthly suicide rates in West of Iran, 20062013
Mehran Rostami,Abdollah Jalilian,Jalal Poorolajal,Behzad Mahaki
International Journal of Preventive Medicine. 2019; 10(1): 78
[Pubmed] | [DOI]


Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  In this article
Discussion and C...
Article Figures
Article Tables

 Article Access Statistics
    PDF Downloaded347    
    Comments [Add]    
    Cited by others 2    

Recommend this journal