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 Table of Contents  
Year : 2019  |  Volume : 10  |  Issue : 1  |  Page : 94

Personalized nutrition: An ancient concept in Iranian traditional medicine

1 Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences; Ala Cancer Prevention and Control Center, Isfahan, Iran
2 Ala Cancer Prevention and Control Center, Isfahan, Iran
3 Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Date of Submission05-Mar-2018
Date of Acceptance07-May-2018
Date of Web Publication07-Jun-2019

Correspondence Address:
Sedigheh Asgary
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.IJPVM_122_18

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How to cite this article:
Zeinalian M, Eshaghi M, Hadian M, Naji H, Asgary S. Personalized nutrition: An ancient concept in Iranian traditional medicine. Int J Prev Med 2019;10:94

How to cite this URL:
Zeinalian M, Eshaghi M, Hadian M, Naji H, Asgary S. Personalized nutrition: An ancient concept in Iranian traditional medicine. Int J Prev Med [serial online] 2019 [cited 2023 Feb 1];10:94. Available from: https://www.ijpvmjournal.net/text.asp?2019/10/1/94/259782

Dear Editor,

Conventionally, nutrition is considered as an essential determinant health-related factor. It influences both preventive and therapeutic aspects of human health and disease.[1] Either quantity or quality of the nutrition is emphasized to warrant the fitness.[2] Nowadays, along with the appearance of some new high-throughput technologies and some comprehensive advanced features of nutrition has been developed using personalized genomic data.[3] Nutrigenomic and nutrigenetics are two newfound scientific disciplines focusing on personalized nutrition according to genomic and genetic variations in different persons.[4] Nutrients present, accordingly, different metabolic behaviors among the people attributed to their variable genomic context.

All omics data including genomics, transcriptomics, proteomics, and metabolomics relevant to nutrition could be analyzed through the high-density microarrays and some other high-throughput technologies.[5] These advanced, however, expensive methods help to differentiate the persons regarding the nutrition-related molecular variants. Hence, personalized nutritional advices may be prescribed according to these individual variants. For example, some recent studies have shown that several particular genomic variants within estrogen receptor 1 gene and Vitamin D receptor gene are in correlation with different metabolic profiles after using Ca and Vitamin D supplements.[6] These personalized molecular features could be used to predict the advantages and disadvantages attributed to the prescription of the nutraceuticals.

Iranian traditional medicine (ITM) is an ancient medical school with several 1000-year-old. According to ITM, every person has an individualized temper or “Mizaj” which should be considered in the nutritional options. On the other hand, all foods and beverages have a temper special to itself.[7],[8] A person would be healthy if there is a balanced state with his/her basic temperament. Interestingly, according to ITM, a diet may be advised to someone but not useful to another, regarding their individual temper.[9] For example, a cold, dry–temper person may feel better with a warm wet fruit such as fig than a cold dry fruit such as cherry. Drinking water may also be more useful in the persons with hot nature of the stomach in comparison to the cold temper stomach people.[7] Moreover, long-term consumption of the incompatible diets could lead to some disorders due to the accumulation and sediment of the bad humors in the vital organs.[10] Moreover, seasonal and geographical differences in climate have been also considered in nutritional habits according to ITM.[8]

Now, there is an important question: whether the personalized nutrition in the current classic medicine according to the advanced microarray technologies is compatible with the personalized nutrition in ITM according to the individual tempers? Unfortunately, no study has been run to evaluate this key question at molecular levels. It seems that designing some studies to investigate the molecular association between the different body tempers and nutrition-related signaling pathways could be uncovered the truth.

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There are no conflicts of interest.

  References Top

Celis-Morales C, Livingstone KM, Marsaux CF, Macready AL, Fallaize R, O'Donovan CB, et al. Effect of personalized nutrition on health-related behaviour change: Evidence from the food4Me European randomized controlled trial. Int J Epidemiol 2017;46:578-88.  Back to cited text no. 1
Wong KA, Kataoka-Yahiro MR. Nutrition and diet as it relates to health and well-being of native Hawaiian Kūpuna (Elders): A systematic literature review. J Transcult Nurs 2017;28:408-22.  Back to cited text no. 2
McDonald D, Glusman G, Price ND. Personalized nutrition through big data. Nat Biotechnol 2016;34:152-4.  Back to cited text no. 3
Ramos-Lopez O, Milagro FI, Allayee H, Chmurzynska A, Choi MS, Curi R, et al. Guide for current nutrigenetic, nutrigenomic, and nutriepigenetic approaches for precision nutrition involving the prevention and management of chronic diseases associated with obesity. J Nutrigenet Nutrigenomics 2017;10:43-62.  Back to cited text no. 4
Trayhurn P, Denyer G. Mining microarray datasets in nutrition: Expression of the GPR120 (n-3 fatty acid receptor/sensor) gene is down-regulated in human adipocytes by macrophage secretions. J Nutr Sci 2012;1:e3.  Back to cited text no. 5
Rojano-Mejía D, Coral-Vázquez RM, Coronel A, Cortes-Espinosa L, del Carmen Aguirre-García M, Valencia-Villalvazo EY, et al. Relation of the estrogen receptor and Vitamin D receptor polymorphisms with bone mineral density in postmenopausal Mexican-Mestizo women. Gene 2014;537:10-4.  Back to cited text no. 6
Nafis EE. (Ali Ebn Abi Hozam Gharshi). Synopsis in medicine (“Al Moojaz fi Teb” or “Al Seydalat ol Mojarrabeh” are original names). In: Aghyl M, editor. Al Moojaz fi Teb. 1st ed. Beyrut, Lebanon: Dar Al Mahjat Ol Bayzae; 2004. p. 67-72.  Back to cited text no. 7
Avicenna Ebn-e-Sina AH. Canon medicina (“Al-Qanon Fel-Tibb”). In: Sharafkandi A, editor. Al-Qanon Fel-Tibb. 10th ed., Vol. 4, 8. Tehran: Sorush; 2010. p. 68-71.  Back to cited text no. 8
Zeinalian M, Eshaghi M, Sharbafchi MR, Naji H, Marandi SM, Asgary S, et al. A comparative study on cancer prevention principles between Iranian traditional medicine and classic medicine. Int J Prev Med 2016;7:61.  Back to cited text no. 9
[PUBMED]  [Full text]  
Borhani M, Khoshzaban F, Jodeiri B, Naseri M, Kamalinejad M. Diet and food in Iranian traditional medicine: Hints for further research. Int J Prev Med 2014;5:1480-1.  Back to cited text no. 10


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