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Effects of coenzyme Q10 supplementation on anthropometric indices in adults: A systematic review and meta-analysis of randomized controlled trials
Abed Ghavami1, Hamed Mohammadi2, Amir Hadi3, Rahele Ziaei2, Elyas Nattagh-Eshtivani4, Mohammad Veysi Sheykhrobat5, Gholamreza Askari2
1 Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Halal Research Center of IRI, FDA, Tehran, Iran
4 Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
5 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Correspondence Address:
Amir Hadi
Halal Research Center of IRI, FDA, Tehran 81745
Iran
Gholamreza Askari
Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan 81745
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/ijpvm.IJPVM_179_19
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Background: Obesity is related to increase in the incidence of morbidity and mortality. Previous studies have led to conflicting results regarding the effect of coenzyme Q10 (CoQ10) supplementation on anthropometric indices. This study aimed to evaluate the efficacy of CoQ10 supplementation on body weight, body mass index (BMI), and waist circumference (WC) through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: PubMed, Scopus, Web of Science, and Cochrane Library as well as the reference lists of the identified relevant RCTs were searched up to March 2019, and weighted mean differences (WMDs) were pooled by using the random-effects model. Results: Twenty RCTs (976 participants) were eligible to be included in the systematic review. The meta-analysis revealed that CoQ10 supplementation had no effect on body weight (WMD = −0.04 kg; 95% confidence interval [CI]: −1.96, 1.6; I2 = 0.0%), BMI (WMD = −0.06 kg/m2; 95% CI: −0.54, 0.42; I2 = 0.0%), and WC (WMD = 0.79 cm; 95% CI: −2.83, 0.04; I2 = 0.0%). Conclusions: CoQ10 supplementation might not improve anthropometric indices. Future well-designed trials are still needed to confirm these results.
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