• Users Online: 730
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Browse Articles Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 33

The Most Important Predictors of Metabolic Syndrome Persistence after 10-year Follow-Up: YHHP Study

1 Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Department of Epidemiology, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Research Unit “Integrated Physiology”, Laboratory of Biochemistry-Human Nutrition, Faculty of Sciences of Bizerte, Carthage University, Tunis, Tunisia
4 Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
5 Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada
6 Baker Heart and Diabetes Institute; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
7 Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
8 Nutrition and Food Security Research Center; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence Address:
Seyedeh Mahdieh Namayandeh
Yazd Cardiovascular Research Center, Afshar Hospital, Jomhouri Blvd., Yazd
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.IJPVM_215_18

Rights and Permissions

Background: Metabolic syndrome (MetS) is one of the world's largest health epidemics, and its management is a major challenge worldwide. The aim of this 10-year follow-up study was to assess the most important predictors of MetS persistence among an Iranian adult population. Methods: In this cohort study, 887 out of 2000 participants with MetS aged 20–74 years in the central part of Iran were followed-up for about 10 years from 2005–2006 to 2015–2016. MetS was defined based on the criteria of NCEP-ATP III adopted for the Iranian population. Cox proportional hazards regression was conducted to evaluate the predictors of MetS persistence in crude- and multivariate-adjusted models. Results: Our analyses showed that 648 out of 887 participants (73%) completed the follow-up and 565 (87.2%) of them had persistence of MetS after 10-year follow-up. There was a significant association between age, weight, body mass index, triglyceride, and waist circumference in participants who had MetS compared to those without MetS after 10-year follow-up (P < 0.05). There was a direct association between increases in the mean changes of systolic/diastolic blood pressure, waist circumference, and low HDL-C and risk of MetS persistence after adjusting the model for sex and age in the total population (Ptrend< 0.05). The trends were the same for women except in diastolic blood pressure. After adjustment for potential confounders, the risk of MetS persistence in men was significantly higher than women (HR = 1.98, 95% CI: 1.38–2.85, Ptrend= 0.001). Conclusions: Most of the risk factors of MetS were positively associated with persistence of MetS. Therefore, modification of lifestyle is recommended to reduce MetS.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded89    
    Comments [Add]    

Recommend this journal