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Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 76

Hypothesis of COVID-19 therapy with sildenafil

1 Researcher, UOC, Infectious and Tropical Diseases, Spaziani Hospital, Frosinone, Italy
2 Biochemistry Senior Scientist Consultant, University Milan, Italy
3 Pharmacological Researcher, ASST, Frosinone, Italy
4 Department of Radiodiagnostic, Pisa University, Italy
5 Department of Radiodiagnostic, Policliclinico San Donato, Milan University, Italy

Correspondence Address:
Menicagli Roberto
20060 Mediglia
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijpvm.IJPVM_258_20

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Backgound: Bacterial or viral infections often cause acute and severe systemic inflammation, which affects the lungs lipopolysaccharide (LPS), a pathogenic component of the membrane of gram-negative bacteria, stimulates active innate immune cells, monocytes, macrophages to produce inducible nitric oxide synthase (iNOS). Excess production of this compound occurs in COVID-19 resulting in inflammatory cascade and thromboembolism. We intend to propose the use of sildenafil to reduce this production. Method: The analysis of biochemical pathways shows that viral infection produces a high amount of nitric oxide (NO), with an acute inflammatory process. Results: In the case of COVID-19 infection we verified that numerous biochemical processes activate a cascade of inflammatory processes through the activation of iNOS with uncontrolled generation of (NO). Conclusions: iNOS is the cause of damage to host cells with a consequent pulmonary thromboembolic lung phenomenon in a contest of interstitial pneumonia. This study proposes the use of sildenafil to counter the inflammatory cascade and thromboembolic episodes.

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