• Users Online: 1440
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Browse Articles Search Archives Submit article Instructions Subscribe Contacts Login 
BRIEF COMMUNICATION
Year : 2021  |  Volume : 12  |  Issue : 1  |  Page : 35

Pulmonary Covid fibrosis a new pharmaceutic approach


1 Biochemistry, Senior Scientist, University Milan Consultant, Italy
2 Researcher UOC, Infectious and Tropical Diseases, Spaziani Hospital Frosinone, Italy
3 Pharmacological Researcher, ASST Frosinone, Italy
4 Radiodiagnostic Department, Pisa University, Italy
5 Policliclinico San Donato Radiodiagnostic Department, Milan University, Italy

Correspondence Address:
Roberto Menicagli
Biochemistry, Senior Scientist, University Milan Consultant, Mediglia - 20060
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijpvm.IJPVM_462_20

Rights and Permissions

Background: Patient's post-COVID may develop chronic irreversible respiratory failure with “widespread signs of pulmonary fibrosis.” Our study analyzed the causes of this fibrosis to propose a therapeutic protocol. Methods: Identification of the biochemical causes of fibrosis in COVID-19 analysing the literature and chest CT. Results: The CT imaging shows pulmonary fibrosis. The viral infection produces “interleukin-6”, which binds to its receptor, in MUC1 of lung epithelial cells. The biochemical response of the cells promotes an over-expression of MUC1 with fibrosis. Interleukin6 also causes a metabolic imbalance in NO that promotes clots and atherosclerosis of the pulmonary vessels. These results show to promote NO endothelia's formation to block both the excessive expression of MUC1 and the atherosclerosis effect of the vessels. Conclusions: This study proposes to inhibit phosphodiesterase by vasodilatation of the pulmonary vascular bed and the MUC1 over expression by interleukin6, the Sildenafil with the SGLT2 and N-Acetylcysteine.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed404    
    Printed6    
    Emailed0    
    PDF Downloaded49    
    Comments [Add]    

Recommend this journal