Users Online: 992
Home
About us
Editorial board
Ahead of print
Browse Articles
Search
Archives
Submit article
Instructions
Subscribe
Contacts
Login
» Articles published recently
To view other articles click corresponding year from the navigation links on the left side.
All
|
Brief Communication
|
Brief Communications
|
Case Report
|
Case Reports
|
Commentary
|
Corrected and Republished
|
Editorial
|
Editorials
|
Erratum
|
Letter To Editor
|
Letter to Editors
|
Letters to Editor
|
Mini-Review Article
|
Opinion
|
Original Article
|
Original Articles
|
Original Research
|
Retraction Notice
|
Review Article
|
Review Articles
|
Review Protocol
|
Review Study
|
Short Communication
|
Short Communications
|
Systematic Review
|
Systematic Review and Meta.Analysis
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Show all abstracts
Show selected abstracts
Export selected to
Add to my list
Brief Communication:
Preventive role of endothelin antagonist on kidney ischemia: Reperfusion injury in male and female rats
Nazgol Esmalian Afyouni, Hanieh Halili, Fatemeh Moslemi, Mehdi Nematbakhsh, Ardeshir Talebi, Soheila Shirdavani, Maryam Maleki
Int J Prev Med
2015, 6:128 (23 December 2015)
DOI
:10.4103/2008-7802.172549
PMID
:26900442
Background:
Renal ischemia/reperfusion injury (RIRI) is the most common cause of acute kidney injury. We tested the protective role of endothelin-1 receptor blocker; bosentan (BOS) in animal model of RIRI in two different genders.
Methods:
Male and female Wistar rats were assigned as sham operated (sham), control group (ischemia), and case group (ischemia + BOS) treated with BOS (50 mg/kg) 2 h before bilateral kidney ischemia induced by clamping renal vessels for 45 min followed by 24 h of renal reperfusion.
Results:
The RIRI significantly increased the serum levels of blood urea nitrogen and creatinine in both genders (
P
< 0.05). These values were significantly decreased by BOS in both genders. In male rats, the serum levels of malondialdehyde in the ischemia + BOS group were decreased significantly when compared with ischemia group (
P
< 0.05).
Conclusions:
BOS can be used in both genders to attenuate kidney ischemia injury possibly due to its effect in the renal vascular system.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (7) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Advanced Search
Month wise articles
Figures next to the month indicate the number of articles in that month
2022
February
[
2
]
2019
October
[
2
]
2018
July
[
1
]
February
[
1
]
2017
July
[
1
]
June
[
1
]
May
[
1
]
April
[
1
]
2016
December
[
1
]
November
[
1
]
July
[
1
]
May
[
1
]
April
[
1
]
March
[
1
]
February
[
1
]
January
[
1
]
2015
December
[
1
]
November
[
1
]
October
[
1
]
September
[
1
]
August
[
1
]
July
[
1
]
June
[
2
]
May
[
1
]
March
[
4
]
Sitemap
|
What's New
Feedback
|
Copyright and Disclaimer
|
Privacy Notice
© International Journal of Preventive Medicine | Published by Wolters Kluwer -
Medknow
Online since 2
nd
January, 2015