As an important group of health problems, glucose metabolism disorders are associated with a number of diseases as well as mortality rate. Recently, studies have demonstrated that the consumption of decaffeinated coffee-enriched chlorogenic acid (CGA) can reduce the risk of diabetes and blood glucose rise, while the results of some previous studies have shown an opposite effect. Hence, a systematic search was conducted based on literature search and appropriate keywords through PubMed, Google Scholar, Web of Knowledge, Science direct, Medline, Cochrane, and Scopus databases from 2003 to 2018. After searching, 1593 articles were found. Then, we excluded papers based on the duplication and relevant for title and abstract, whereas 25 relevant articles remained for checking eligibility criteria. Since only randomized clinical trials studies (RCTs) could be included in the current study, six RCTs remained in end-stage for qualitative synthesis. The results of reviewed studies showed no significant effect of decaffeinated coffee-enriched CGA on blood glucose concentration. Although recent studies have suggested the effectiveness of decaffeinated coffee-enriched CGA on blood glucose in animals, and there are various mechanisms for this effect, and the result of our review showed that there is not sufficient evidence for this claim in healthy humans. Hence, further research in this area seems necessary.

Coffee and green tea are two of most usual consumed beverages in the world which have several benefit components. Coffee and green tea have significantly inverse correlation with obesity, diabetes, and cardiovascular diseases. Adiponectin and leptin are the adipokines mostly secreted from adipose tissue and play the important roles on the status of chronic diseases. In the present study, we aimed to review the evidence about relationship between these beverages and adiponectin and leptin levels. We searched in PubMed to January 2013 using several key words such as coffee, green tea, caffeine, leptin, adiponectin, and adipokines. Finally, most related articles were recruited in this regard. Several findings suggested the positive association between coffee and adiponectin level. Different studies showed contradictory results regarding green tea and adiponectin level. However, most of them reported the positive role of green tea in adiponectin concentration. Fewer studies are conducted about the association between these beverages and leptin, and their results are controversial. More longitudinal investigations should be conducted in this regard to declare these associations.