Each research roves around the P value. A value less than 0.05 is considered to be statistically significant. Very few researchers are aware of the history, real-world significance, statistical insight, and in-depth criticism about this monumental alphabet of research. This article will provide detailed insight into the most common molecule of research which will be rewarding for the young students and researchers in the primary world of research. It is not a simple value; it is the longest and broadest description of research squeezed to a number for the ground level worker to the principal investigator. The present review will provide a detailed and unique insight into the P value which would be rewarding for the primary care physicians toward translating research into their clinical practice.