Year : 2015 | Volume
: 6 | Issue : 1 | Page : 104-
Effect of Vitamin E on oxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial
Zeinab Salehi, Mahnaz Roayaei
Department of Radiotherapy and Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Background: Peripheral neuropathy is one of the most important limitations of oxaliplatin base regimen, which is the standard for the treatment of colorectal cancer. Evidence has shown that Vitamin E may be protective in chemotherapy-induced peripheral neuropathy. The aim of this study is to evaluate the effect of Vitamin E administration on prevention of oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer.
Methods: This was a prospective randomized, controlled clinical trial. Patients with colorectal cancer and scheduled to receive oxaliplatin-based regimens were enrolled in this study. Enrolled patients were randomized into two groups. The first group received Vitamin E at a dose of 400 mg daily and the second group observed, until after the sixth course of the oxaliplatin regimen. For oxaliplatin-induced peripheral neuropathy assessment, we used the symptom experience diary questionnaire that completed at baseline and after the sixth course of chemotherapy. Only patients with a score of zero at baseline were eligible for this study.
Results: Thirty-two patients were randomized to the Vitamin E group and 33 to the control group. There was no difference in the mean peripheral neuropathy score changes (after − before) between two groups, after sixth course of the oxaliplatin base regimen (mean difference [after − before] of Vitamin E group = 6.37 ± 2.85, control group = 6.57 ± 2.94; P = 0.78). Peripheral neuropathy scores were significantly increased after intervention compared with a base line in each group (P < 0.001).
Conclusions: The results from this current trial demonstrate a lack of benefit for Vitamin E in preventing oxaliplatin-induced peripheral neuropathy.
Department of Radiotherapy and Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Hezarjerib Avenue, Isfahan
|How to cite this article:|
Salehi Z, Roayaei M. Effect of Vitamin E on oxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial.Int J Prev Med 2015;6:104-104
|How to cite this URL:|
Salehi Z, Roayaei M. Effect of Vitamin E on oxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial. Int J Prev Med [serial online] 2015 [cited 2022 Jan 22 ];6:104-104
Available from: https://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2015;volume=6;issue=1;spage=104;epage=104;aulast=Salehi;type=0