International Journal of Preventive Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 61-

Effects of flaxseed oil omega-3 fatty acids supplementation on regression and metabolic status in endometrial hyperplasia: A randomized, double-blind, placebo-controlled trial


Mehri Jamilian1, Leili Khademi2, Zahra Vahedpoor3, Fereshteh Bahmani4, Samaneh Mahmoodi3, Mohsen Taghizadeh4, Zatollah Asemi4 
1 Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
2 Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran
3 Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran
4 Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran

Correspondence Address:
Zatollah Asemi
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan
I.R. Iran

Background: Data on the effects of omega-3 fatty acid supplementation on clinical symptoms and metabolic profiles in patients with endometrial hyperplasia (EH) are limited. This intervention was performed to assess the effects of omega-3 fatty acid supplementation on clinical symptoms and metabolic profiles in patients with endometrial hyperplasia (EH). Methods: This randomized, double-blind, placebo-controlled trial was conducted among 40 women diagnosed with simple endometrial hyperplasia (EH). EH diagnosis was performed based on specific diagnostic procedures of biopsy. Participants were randomised into two groups to intake 1,000 mg omega-3 fatty acid supplements from flaxseed oil (n = 20) or placebo (n = 20), twice a day for 12 weeks. Fasting blood samples were taken at baseline and after the 12-week intervention to determine related markers. Results: Compared with the placebo, omega-3 fatty acid supplementation significantly decreased fasting plasma glucose (FPG) (-7.1 ± 9.6 vs. +2.0 ± 4.9 mg/dL, P = 0.001), serum insulin levels (-1.5 ± 4.6 vs. +1.6 ± 3.9 μIU/mL, P = 0.02) and homeostasis model of assessment-insulin resistance (HOMA-IR) (-0.4 ± 1.1 vs. +0.4 ± 1.0, P = 0.02). In addition, a significant increase in plasma total antioxidant capacity (TAC) (+102.6 ± 69.6 vs. +5.0 ± 37.1 mmol/L, P < 0.001) and total glutathione (GSH) levels (+63.6 ± 84.9 vs. -3.0 ± 69.4 μmol/L, P = 0.01) were seen following the supplementation of omega-3 fatty acid compared with the placebo. Omega-3 fatty acid supplementation had no significant effect on regression, lipid profiles, and other biomarkers of inflammation and oxidative. Conclusions: In conclusion, we found that omega-3 fatty acid administration for 12 weeks to subjects with EH significantly improved FPG, insulin, HOMA-IR, TAC and GSH levels, but did not influence regression, lipid profiles, and other biomarkers of inflammatory and oxidative stress.


How to cite this article:
Jamilian M, Khademi L, Vahedpoor Z, Bahmani F, Mahmoodi S, Taghizadeh M, Asemi Z. Effects of flaxseed oil omega-3 fatty acids supplementation on regression and metabolic status in endometrial hyperplasia: A randomized, double-blind, placebo-controlled trial.Int J Prev Med 2019;10:61-61


How to cite this URL:
Jamilian M, Khademi L, Vahedpoor Z, Bahmani F, Mahmoodi S, Taghizadeh M, Asemi Z. Effects of flaxseed oil omega-3 fatty acids supplementation on regression and metabolic status in endometrial hyperplasia: A randomized, double-blind, placebo-controlled trial. Int J Prev Med [serial online] 2019 [cited 2021 Apr 20 ];10:61-61
Available from: https://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=61;epage=61;aulast=Jamilian;type=0