International Journal of Preventive Medicine

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 10  |  Issue : 1  |  Page : 68-

Protective effect of zinc supplementation on renal ischemia/reperfusion injury in rat: Gender-related difference


Fatemeh Moslemi1, Ardeshir Talebi1, Mehdi Nematbakhsh2 
1 Department of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Physiology, Water and Electrolytes Research Center; Department of Physiology, Isfahan University of Medical Sciences; IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran

Correspondence Address:
Mehdi Nematbakhsh
Department of Physiology, Water and Electrolytes Research Center, Isfahan University of Medical Sciences, Isfahan
Iran

Background: Zinc (Zn) knows as essential microelement which prevents oxidative stress. The effect of Zn supplement on renal function parameters in rats subjected to renal ischemia-reperfusion (IR) injury was investigated. Methods: Male and female rats were subjected to renal IR with and without Zn sulfate (10 mg/kg/day for 5 days) supplementation. The kidney function markers and histology findings in Zn-treated group were compared with sham and control groups. Results: The serum levels of blood urea nitrogen and creatinine (Cr) and kidney tissue damage score were increased significantly after renal injury (P < 0.05) gender dependently, but no alterations were observed for these markers in Zn-treated animals after renal IR injury. Cr clearance was significantly different between genders (P < 0.05); however, Zn supplementation increased the Cr clearance and kidney nitrite level significantly in male rats (P < 0.05). Zn also increased urine flow in female (P < 0.05), but it did not alter urine load of Na (UNaV) and percentage of Na excretion (ENa%). Conclusions: Zn may improve renal function after IR injury gender dependently.


How to cite this article:
Moslemi F, Talebi A, Nematbakhsh M. Protective effect of zinc supplementation on renal ischemia/reperfusion injury in rat: Gender-related difference.Int J Prev Med 2019;10:68-68


How to cite this URL:
Moslemi F, Talebi A, Nematbakhsh M. Protective effect of zinc supplementation on renal ischemia/reperfusion injury in rat: Gender-related difference. Int J Prev Med [serial online] 2019 [cited 2021 Apr 18 ];10:68-68
Available from: https://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2019;volume=10;issue=1;spage=68;epage=68;aulast=Moslemi;type=0